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Dr. Piccolo was born and raised in the same neighborhood where she now practices. She attended Rutgers University in Newark, where she was inducted into the Phi Beta Kappa academic honor society. After attending Rutgers for three years, she was accepted for early admissions into the University of Medicine and Dentistry of New Jersey, where Dr. Piccolo was awarded induction into the Omicron Kappa Upsilon Honorary Dental Society. She graduated in 1985 with a Doctorate in Medical Dentistry.
Dr. Piccolo is married to Eric Piccolo, a teacher in Jersey City's Dickinson High School, their alma mater. Together they have raised three beautiful children: Eric, a graduate of Fairleigh Dickinson University, is employed as an auditor. Angelica, a graduate of Rutgers University and Montclair State University's Masters in Teaching program, is currently employed as a Physical Education teacher, and coaches volleyball and swimming. David, a senior at Rutgers University, is pursuing a career as an actuary.